BDBM50458023 CHEMBL4214282

SMILES CC[Si](CC)(CC)c6ccc(N3[C@H](c2ccc(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)cc2)CC[C@H]3c5ccc(NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)cc5)cc6

InChI Key InChIKey=CZTPXCSBMCSWAB-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50458023   

TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.00300nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.000800nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of NS5A in HCV genotype 3a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of NS5A in HCV genotype 5a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.445nMAssay Description:Inhibition of NS5A in HCV genotype 6a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458023(CHEMBL4214282)
Affinity DataEC50:  0.000100nMAssay Description:Inhibition of NS5A in HCV genotype 4a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed