BDBM50458018 CHEMBL4216436

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)[Si](C)(C)C)c1ccc(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)C(C)C)cc1

InChI Key InChIKey=VFBCVEYOCNQRFL-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50458018   

TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.000100nMAssay Description:Inhibition of NS5A in HCV genotype 4a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of NS5A in HCV genotype 5a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.0140nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.00250nMAssay Description:Inhibition of NS5A in HCV genotype 2a JFH-1 infected in human Huh7.5.1 cells assessed as reduction in viral replication after 3 days by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.0380nMAssay Description:Inhibition of NS5A in HCV genotype 3a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  0.00400nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chia Tai Tianqing Pharmaceutical Group

Curated by ChEMBL
LigandPNGBDBM50458018(CHEMBL4216436)
Affinity DataEC50:  1.41nMAssay Description:Inhibition of NS5A in HCV genotype 6a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in vir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed