BDBM50457708 CHEMBL4202824

SMILES CC(C)Oc1ccc(cc1C(=O)N1Cc2cn(nc2C1)-c1ccccc1)C#N

InChI Key InChIKey=LGQMKDJDLRJGMM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50457708   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at 10 nM to 10 uM at holding potential of -80 mV measured after 5 mins by QPatch automated patch clamp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 7 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A5 in human liver microsomes using midazolam as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Rat)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 161nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 105nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human GlyT2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50457708(CHEMBL4202824)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed