BDBM50457629 CHEMBL4211776

SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)C(=O)NCCCCCCCC(=O)Nc2ccccc2N)n1

InChI Key InChIKey=IATHFICEGBTXSK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457629   

TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457629(CHEMBL4211776)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457629(CHEMBL4211776)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457629(CHEMBL4211776)
Affinity DataIC50: 660nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457629(CHEMBL4211776)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorogenic substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed