BDBM50457627 CHEMBL4212117

SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)C(=O)NCCCCCCC(=O)NO)n1

InChI Key InChIKey=PSNSRJNHZPJVJH-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50457627   

TargetVascular endothelial growth factor receptor 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 46nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 380nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 111nMAssay Description:Inhibition of PDGFRbeta (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 72nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorogenic Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR-1 (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 113nMAssay Description:Inhibition of VEGFR-3 (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 409nMAssay Description:Inhibition of FGFR1 (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 163nMAssay Description:Inhibition of C-kit (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluorogenic Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50457627(CHEMBL4212117)
Affinity DataIC50: 581nMAssay Description:Inhibition of C-fms (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed