BDBM504572 (S)-5-(Benzo[d]oxazol-2-yl)-4-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)morpholin-3-one::US11066396, Example 35

SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](COCC1=O)c1nc2ccccc2o1

InChI Key InChIKey=NXJJIJDRIRMSCO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 504572   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504572((S)-5-(Benzo[d]oxazol-2-yl)-4-(4-(5-(trifluorometh...)
Affinity DataIC50: 6nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
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TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504572((S)-5-(Benzo[d]oxazol-2-yl)-4-(4-(5-(trifluorometh...)
Affinity DataIC50: 55nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504572((S)-5-(Benzo[d]oxazol-2-yl)-4-(4-(5-(trifluorometh...)
Affinity DataIC50: 2nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504572((S)-5-(Benzo[d]oxazol-2-yl)-4-(4-(5-(trifluorometh...)
Affinity DataIC50: 400nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent