BDBM50455538 CHEMBL4214092

SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cn2c(cnc2cn1)-c1ccc(cc1)C(=O)NO

InChI Key InChIKey=CQPDKJQEKIKEFC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50455538   

TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)
Affinity DataIC50: 60nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Agency For Science, Technology and Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)
Affinity DataIC50: 30nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed