BDBM50455476 CHEBI:6922::Micheliolide

SMILES [H][C@@]12CCC(C)=C3CC[C@@](C)(O)[C@]3([H])[C@@]1([H])OC(=O)C2=C

InChI Key InChIKey=RDJAFOWISVMOJY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50455476   

TargetPyruvate kinase PKM(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50455476(CHEBI:6922 | Micheliolide)
Affinity DataEC50:  6nMAssay Description:Activation of recombinant human PKM2 expressed in Escherichia coli BL21 at 4 uM incubated for 50 mins measured over 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50455476(CHEBI:6922 | Micheliolide)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of NLRP3 inflammasome in mouse J774.A1 cells assessed as reduction in LPS-induced IL-1beta releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50455476(CHEBI:6922 | Micheliolide)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human primary glial cells assessed as reduction in LPS-induced IL-1beta releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed