BDBM504553 (S)-6-(Benzo[d]thiazol-2-yl)-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-1)phenyl)piperidin-2-one::US11066396, Example 25

SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](CCCC1=O)c1nc2ccccc2s1

InChI Key InChIKey=HVVDODUDCRCSMB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504553   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504553((S)-6-(Benzo[d]thiazol-2-yl)-1-(4-(5-(trifluoromet...)
Affinity DataIC50: 8.10nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504553((S)-6-(Benzo[d]thiazol-2-yl)-1-(4-(5-(trifluoromet...)
Affinity DataIC50: 220nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504553((S)-6-(Benzo[d]thiazol-2-yl)-1-(4-(5-(trifluoromet...)
Affinity DataIC50: 740nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent