BDBM50455095 CHEMBL4206972

SMILES COc1ccc(cn1)C(N)=O

InChI Key InChIKey=KXDSMFBEVSJYRF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50455095   

TargetNicotinamide N-methyltransferase(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of human NNMT at 30 uM preincubated for 30 mins followed by nicotinamide substrate and SAM addition measured after 60 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human NNMT measured after 20 mins by luminescence based methyltransferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetNicotinamide N-methyltransferase(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human NNMT preincubated for 30 mins followed by substrate, cofactor addition and measured after 60 mins using nicotinamide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Mouse)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse NNMT preincubated for 30 mins followed by substrate, cofactor addition and measured after 60 mins using nicotinamide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of endogenous human NNMT overexpressed in human U2OS cells assessed incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Mouse)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50455095(CHEMBL4206972)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of endogenous mouse NNMT overexpressed in murine 3T3-L1 cells assessed incubated for 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed