BDBM50454599 CHEMBL4216368

SMILES Oc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=FTVGDRKKJVKLHA-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50454599   

TargetSerum paraoxonase/arylesterase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of microsomal epoxide hydrolase (unknown origin) expressed in baculovirus system using CMNMC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carboxylesterase 1 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carboxylesterase 2 expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/arylesterase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON2 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetArylacetamide deacetylase(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of AADAC (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 350nMAssay Description:Inhibition of FAAH in mouse brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1nMAssay Description:Inhibition of soluble epoxide in rat brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 120nMAssay Description:Inhibition of human FAAH expressed in baculovirus-infected High Five cells S9 fraction using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of soluble epoxide in mouse brain microsomes using CMNPC substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerum paraoxonase/lactonase 3(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PON3 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of FAAH in rat brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50454599(CHEMBL4216368)
Affinity DataKi:  9.10nMAssay Description:Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed