BDBM50454278 CHEMBL4207026

SMILES Cc1cc(C)cc(c1)S(=O)(=O)n1c(SCC(=O)Nc2ccc(cc2)C(O)=O)nc2ccccc12

InChI Key InChIKey=NPTAZCFEZGQOLN-UHFFFAOYSA-N

Data  1 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50454278   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50:  1.35E+3nMAssay Description:Inhibition of reverse transcriptase E138K mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant wild-type HIV-1 3B reverse transcriptase p66/p51 RNA-dependent DNA polymerase activity expressed in Escherichia coli JM109 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibition of reverse transcriptase K103N mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50:  2.36E+4nMAssay Description:Inhibition of reverse transcriptase Y181C mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50: >1.24E+5nMAssay Description:Inhibition of reverse transcriptase F227L/V106A double mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50: >1.24E+5nMAssay Description:Inhibition of reverse transcriptase K103N/Y181C double mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50:  1.82E+3nMAssay Description:Inhibition of reverse transcriptase L100I mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50454278(CHEMBL4207026)
Affinity DataEC50: >1.24E+5nMAssay Description:Inhibition of reverse transcriptase Y188L mutant in HIV1 infected in human MT4 cells assessed as protection against virus induced cytotoxicity after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed