BDBM50453889 CHEMBL4207984

SMILES Oc1ccc(cc1-c1nc(NCc2cccnc2)c2ccccc2n1)C#N

InChI Key InChIKey=BPTUCHARDQHTEK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50453889   

TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of wild type recombinant N-terminal GST-tagged human EGFR catalytic domain expressed in Sf9 insect cells using poly-Glu-Tyr (4:1) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human EGFR d746-750/T790M/C797S mutant using poly-Glu-Tyr (4:1) as substrate after 2 hrs in presence of [gamma-33P]-ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 18nMAssay Description:Inhibition of human EGFR del19/T790M/C797S mutant assessed as enzyme remaining activity using poly-Glu-Tyr peptide substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50453889(CHEMBL4207984)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human wild type EGFR assessed as enzyme remaining activity using poly-Glu-Tyr peptide substrate incubated for 2 hrs in presence of [gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed