BDBM50453140 CHEMBL4213986

SMILES CC(C)Oc1cc(C2CCN(CCOCCOCCNC(=O)CNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=XIRQUXILNXIWDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453140   

TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453140(CHEMBL4213986)
Affinity DataIC50: 40nMAssay Description:Induction of ALK degradation in human KARPAS299 cells after 16 hrs by immunoblot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453140(CHEMBL4213986)
Affinity DataIC50: 10nMAssay Description:Induction of ALK degradation in human NCI-H3122 cells after 16 hrs by immunoblot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453140(CHEMBL4213986)
Affinity DataIC50: 50nMAssay Description:Induction of ALK degradation in human Kelly cells after 16 hrs by immunoblot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453140(CHEMBL4213986)
Affinity DataIC50: 971nMAssay Description:Inhibition of N-terminal flag-tagged NanoLuc fused ALK kinase domain (1072 to 1410 residues) (unknown origin) expressed in mouse BaF3 cells assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed