BDBM50453121 CHEMBL4215679

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=NREDIDBJPFQPKQ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453121   

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453121(CHEMBL4215679)
Affinity DataEC50:  0.354nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453121(CHEMBL4215679)
Affinity DataEC50:  1.98nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453121(CHEMBL4215679)
Affinity DataEC50:  0.0130nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453121(CHEMBL4215679)
Affinity DataEC50:  0.0710nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed