BDBM50453105 CHEMBL3960757

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)[C@H]1CC[C@@H](N1c1ccc(cc1)C(C)(C)C)c1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=NREDIDBJPFQPKQ-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50453105   

TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 4a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.152nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.268nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2b assessed as decrease in viral replication after 3 days by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.148nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453105(CHEMBL3960757)
Affinity DataEC50:  0.0130nMAssay Description:Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed