BDBM50452872 CHEMBL4210894

SMILES c1cn-2c(n1)C(=O)N(c3c2cc(c(c3)N4CC[C@@H](C4)N)F)C5CC5

InChI Key InChIKey=FBYRCTKKXBIHCM-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452872   

LigandPNGBDBM50452872(CHEMBL4210894)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG transfected in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50452872(CHEMBL4210894)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4-mediated midazolam metabolism in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50452872(CHEMBL4210894)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase A2B2 using relaxed pNO1 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50452872(CHEMBL4210894)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4-mediated testosterone metabolism in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed