BDBM50452609 CHEMBL4206099

SMILES CC[C@H](c1ccc(c(c1)N)C(=O)O)NC(=O)N2C/C(=N/Oc3ccccc3)/NC[C@H](C2=O)Cc4cc(ccc4OC)Cl

InChI Key InChIKey=LHASZEBEQGPCFM-UHFFFAOYSA-N

Data  1 IC50  1 Koff

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452609   

TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataKon:  2.10E-8M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 12.5 to 200 nM by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)