BDBM50452216 CHEMBL4215537::US10647727, Example 13

SMILES Cn1ncc2c(NC3(CC3)c3ccc(cc3)C(F)(F)F)nc(nc12)C1CC1

InChI Key InChIKey=NVBNLGCHMMFYDD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452216   

LigandPNGBDBM50452216(CHEMBL4215537 | US10647727, Example 13)
Affinity DataKi:  20nMAssay Description:Binding affinity to PDE2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452216(CHEMBL4215537 | US10647727, Example 13)
Affinity DataKi:  20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

LigandPNGBDBM50452216(CHEMBL4215537 | US10647727, Example 13)
Affinity DataKi:  55nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452216(CHEMBL4215537 | US10647727, Example 13)
Affinity DataKi:  72nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent