BDBM50452176 CHEMBL4213904

SMILES Nc1nc(N)c2cc(NCc3ccc(CCNC(=O)c4ccc(cc4)[N+]([O-])=O)cc3)ccc2n1

InChI Key InChIKey=NRZDHPATDCAABX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452176   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50452176(CHEMBL4213904)
Affinity DataIC50: 56nMAssay Description:Inhibition of Plasmodium falciparum DHFR using DHF as substrate preincubated for 15 mins followed DHF addition measured after 15 mins by spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCysteine proteinase falcipain 2a(malaria parasite P. falciparum)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50452176(CHEMBL4213904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum FP2 using Z-Leu-Arg-AMC as substrate preincubated for 30 min followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed