BDBM50452068 CHEMBL4206293

SMILES CC1(C)Cc2c(O1)c(cc1nc(Nc3c(Cl)cccc3Cl)[nH]c21)C(=O)NCC1CC1

InChI Key InChIKey=VCOAFVTZDRCOGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452068   

TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452068(CHEMBL4206293)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human mPGES1 expressed in CHO cells using PGH2 as substrate pretreated for 10 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452068(CHEMBL4206293)
Affinity DataIC50: 47nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 production pretreated for 30 mins followed by IL-1beta additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed