BDBM50451883 CHEMBL4211076

SMILES Cc1nnc2sc(C(=O)N3CC(C3)c3ccccc3)c(N)c2c1C

InChI Key InChIKey=QOAFWVIRCVXMMQ-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50451883   

TargetMuscarinic acetylcholine receptor M1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human M1 receptor assessed as increase in acetylcholine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human M3 receptor assessed as increase in acetylcholine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50:  72nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50:  72nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50451883(CHEMBL4211076)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human M5 receptor assessed as increase in acetylcholine-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed