BDBM50451566 CHEMBL4216985

SMILES CCN[C@@H]1CCC=C([C@H]1COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1ccc(F)cc1

InChI Key InChIKey=FPPPUMRUUDDRRH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50451566   

TargetCytochrome P450 3A4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 2.16E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50451566(CHEMBL4216985)
Affinity DataIC50: 48nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed