BDBM50450836 CHEMBL4216939

SMILES OCc1c(cccc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC#N)N1CCOc2cc(cc(F)c2C1=O)C1CC1

InChI Key InChIKey=ZFHWVNBXUFXNKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50450836   

TargetTyrosine-protein kinase BTK(Mouse)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450836(CHEMBL4216939)
Affinity DataIC50: 51nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450836(CHEMBL4216939)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed