BDBM50450629 CHEMBL4177187

SMILES [#6]-[#6]-[#8]-[#6](=O)-c1cnn(c1C(F)(F)F)-c1ccc(-[#7]-[#6](=O)-[#6](\Cl)=[#6](/Cl)Cl)cc1

InChI Key InChIKey=YWOHDXZOBNZHFP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50450629   

TargetStromal interaction molecule 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of STIM1/STIM2/Orai1 (unknown origin) expressed in mouse BV2 cells assessed as reduction of store-operated calcium entry at 100 uM preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetShort transient receptor potential channel 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 500nMAssay Description:Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 540nMAssay Description:Inhibition of YFP-tagged TRPC3 (unknown origin) expressed in HEK293 cells assessed as reduction carbhocol-induced receptor operated Calcium influx af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 700nMAssay Description:Inhibition of TRPC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCalcium release-activated calcium channel protein 1(Rat)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 540nMAssay Description:Inhibition of ORAI/STIM1 in thapsigargin treated rat RBL2H3 cells assessed as reduction in store-operated calcium entry after 5 mins by fura-2-AM dye...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 530nMAssay Description:Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in absence of extracellular calcium by whole cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetShort transient receptor potential channel 3(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 470nMAssay Description:Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in presence of 2 mM extracellular calcium by who...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetShort transient receptor potential channel 3(Mouse)
The University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50450629(CHEMBL4177187)
Affinity DataIC50: 700nMAssay Description:Inhibition of mouse TRPC3 expressed in HEK293 cells assessed as inhibition of Ca2+ influx by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed