BDBM50450624 CHEMBL4176696

SMILES c1cc(ccc1Oc2ccc(cc2n3cc(nn3)C(=O)NO)Cl)F

InChI Key InChIKey=NXLUFTCWMNFMML-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50450624   

TargetHistone deacetylase 8(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450624(CHEMBL4176696)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Blood fluke)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50450624(CHEMBL4176696)
Affinity DataIC50: 504nMAssay Description:Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)