BDBM50450303 CHEMBL4177034

SMILES CC(C)[C@H](NC(=O)c1ccc(o1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1)C(=O)NC[C@@H](O)CO

InChI Key InChIKey=SQWPYMHLYZKCEN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50450303   

TargetNeutrophil collagenase(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human MMP8 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human MMP14 expressed in Escherichia coli using fTHP-15 as substrate preincubated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human MMP9 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of recombinant human full length MMP13 expressed in mouse NS0 cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 172nMAssay Description:Inhibition of recombinant human MMP2 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Graz University of Technology

Curated by ChEMBL
LigandPNGBDBM50450303(CHEMBL4177034)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human MMP1 expressed in mouse NS0 cells using Knight substrate preincubated for 30 mins followed by substrate addition by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed