BDBM50449547 CHEMBL4163870

SMILES Cc1nc2CCCc2c(Nc2c[nH]nc2C(=O)Nc2ccc(cc2)N2CCNCC2)n1

InChI Key InChIKey=DXUDRTZDTCQOLU-UHFFFAOYSA-N

Data  11 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50449547   

TargetVascular endothelial growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 220nMAssay Description:Inhibition of human FLT1 by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 95nMAssay Description:Inhibition of human KDR by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 23nMAssay Description:Inhibition of human FLT4 by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FLT3 D835Y mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human FLT3 by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 7nMAssay Description:Inhibition of human FLT3 F594_R595insR mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human FLT3 F594_R595insREY mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 15nMAssay Description:Inhibition of human FLT3 ITD-NPOS mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 13nMAssay Description:Inhibition of human FLT3 ITD-W51 mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human FLT3 R595_E596 mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataIC50: 15nMAssay Description:Inhibition of human FLT3 Y591-V592 mutant by Hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to human FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50449547(CHEMBL4163870)
Affinity DataKd:  13nMAssay Description:Binding affinity to human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed