BDBM50449530 CHEMBL4173438

SMILES Cn1ccc2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)ncnc12

InChI Key InChIKey=UFRZVYHVFUXUEN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50449530   

TargetSerine/threonine-protein kinase B-raf(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449530(CHEMBL4173438)
Affinity DataIC50: 24nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449530(CHEMBL4173438)
Affinity DataIC50: 52nMAssay Description:Inhibition of wild-type BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449530(CHEMBL4173438)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449530(CHEMBL4173438)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system by Z'-Lyte ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed