BDBM50449527 CHEMBL4173144

SMILES Cn1ncc2c(Oc3ccc4n(C)c(Nc5ccc(F)cc5)nc4c3)ncnc12

InChI Key InChIKey=RAFSWDCWKHRJKB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50449527   

TargetVascular endothelial growth factor receptor 2(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449527(CHEMBL4173144)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system by Z'-Lyte ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50449527(CHEMBL4173144)
Affinity DataIC50: 407nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed