BDBM50448923 CHEMBL3125316::CHEMBL3125317::CHEMBL3125318::CHEMBL3125455::CHEMBL3125456::CHEMBL3125457::CHEMBL3125458

SMILES CCOc1ccc(cc1)Cc2cc(ccc2Cl)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O

InChI Key InChIKey=JVHXJTBJCFBINQ-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50448923   

TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
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TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
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TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 5.04E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 3.99E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium/glucose cotransporter 1(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 7.20nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 6.5nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 7.5nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 2.90nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 7.5nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetSodium/glucose cotransporter 2(Human)
Fudan University

Curated by ChEMBL

LigandBDBM50448923(CHEMBL3125455 | CHEMBL3125318 | CHEMBL3125456 | CH...)Copy SMILESCopy InChI

Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankPC cidPC sidPDBSimilars

In Depth
Date in BDB:
7/26/2014
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL