BDBM50448696 CHEMBL3127869

SMILES O[C@@]12CC3CC(C1)[C@H](NC(=O)c1sc(OCC4(CC4)C#N)nc1C1CC1)C(C3)C2

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50448696   

TargetBifunctional epoxide hydrolase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50: 55nMAssay Description:Inhibition of rat 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant human 11beta-HSD1 using cortisone/[3H]-cortisone as substrate after 5 hrs by reverse-phase HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50: 22nMAssay Description:Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed