BDBM50447512 CHEMBL3115681::US20250129067, Compound ON123300

SMILES CN1CCN(CC1)c2ccc(cc2)Nc3ncc4c(n3)N(C(=O)C(=C4)C#N)C5CCCC5

InChI Key InChIKey=VADOZMZXXRBXNY-UHFFFAOYSA-N

Data  22 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50447512   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 55nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Progentos Therapeutics

US Patent
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 73.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 26nMAssay Description:Inhibition of PDGFRb (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 26nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 11nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 5nMAssay Description:Inhibition of human NUAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 272nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 377nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 600nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 117nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 159nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin) using retinoblastoma as substrate after 30 mins by autoradiography in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 5nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of CDK6/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 10nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 53nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 144nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed