BDBM504474 US11040966, Example 1.54::[4-(4-Bromo-3-chloro-phenyl)-pyrimidin-5-yl]-[(S)-2-(6-methylsulfanyl-1H-benzoimidazol-2-yl)-pyrrolidin-1-yl]-methanone

SMILES CSc1ccc2nc([nH]c2c1)[C@@H]1CCCN1C(=O)c1cncnc1-c1ccc(Br)c(C)c1

InChI Key InChIKey=ZEASBNJWOSZLKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 504474   

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504474([4-(4-Bromo-3-chloro-phenyl)-pyrimidin-5-yl]-[(S)-...)
Affinity DataIC50: 726nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504474([4-(4-Bromo-3-chloro-phenyl)-pyrimidin-5-yl]-[(S)-...)
Affinity DataIC50: 80nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent