BDBM50447181 CHEMBL3113197::US10752581, Compound 67

SMILES COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2cccc(c2)C(C)C)c1O

InChI Key InChIKey=SMFFPQDLUGWSOM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447181   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50: 160nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50: 1.00E+5nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent