BDBM50447175 CHEMBL3113165::US10752581, Compound 35

SMILES COc1cccc(c1O)CNc2ccc(cc2)S(=O)(=O)Nc3nc4ccccc4s3

InChI Key InChIKey=OWHBVKBNNRYMIN-UHFFFAOYSA-N

Data  2 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50447175   

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Mouse)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 12-LOX in mouse BTC3 cells assessed as inhibition of arachidonic acid/calcium ionophore-induced 12-HETE production after 4 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged human epithelial 15-LOX2 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 340nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 9.70E+3nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50: 360nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataKi:  350nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataKi:  720nMAssay Description:Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)