BDBM50446847 CHEMBL3115074

SMILES C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(cc1)C(O)=O

InChI Key InChIKey=ADSVKUMNMQPBKC-UHFFFAOYSA-N

Data  8 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50446847   

TargetProstaglandin E2 receptor EP3 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Rat)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at rat EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 30 mins by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 69nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.63E+3nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  54nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  1.21E+3nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  1.55E+3nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP3 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.27E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.40E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP1 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.75E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent

TargetProstaglandin E2 receptor EP1 subtype(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.75E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed