BDBM50446537 CHEMBL3110100::US9505749, 106

SMILES c1ccc2c(c1)C(=O)NC(=N2)SCCC(=O)NC3CCC(CC3)Oc4ccc(cc4)C#N

InChI Key InChIKey=MCMCBDOVNWSRNM-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50446537   

LigandPNGBDBM50446537(CHEMBL3110100 | US9505749, 106)
Affinity DataIC50: 0.0973nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50446537(CHEMBL3110100 | US9505749, 106)
Affinity DataIC50: 7.57nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandPNGBDBM50446537(CHEMBL3110100 | US9505749, 106)
Affinity DataIC50: 1.76E+3nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandPNGBDBM50446537(CHEMBL3110100 | US9505749, 106)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed