BDBM50446287 CHEMBL3109231

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(cc4)C#N)ccc3c2)cc1

InChI Key InChIKey=PGAQNWMPGDENLH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50446287   

TargetNuclear receptor ROR-gamma(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446287(CHEMBL3109231)
Affinity DataIC50: 6nMAssay Description:Inverse agonist activity at biotinylated human RORgammat LBD expressed in Escherichia coli BL21 assessed as inhibition of SRC1 recruitment after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50446287(CHEMBL3109231)
Affinity DataIC50: 457nMAssay Description:Inverse agonist activity at RORgammat in mouse Th17 cells assessed as effect on cell differentiation measured as IL-17 level after 3 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed