BDBM50445901 CHEMBL3105804::US10301272, Example 211

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Cc3ccccc3)s2)-c2ccccc2)cc1

InChI Key InChIKey=UVPYBRXTAWOMSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50445901   

TargetNuclear receptor ROR-gamma(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445901(CHEMBL3105804 | US10301272, Example 211)
Affinity DataIC50: 631nMAssay Description:Inhibition of APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM50445901(CHEMBL3105804 | US10301272, Example 211)
Affinity DataIC50: 1.59E+3nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM50445901(CHEMBL3105804 | US10301272, Example 211)
Affinity DataIC50: 501nMAssay Description:Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM50445901(CHEMBL3105804 | US10301272, Example 211)
Affinity DataIC50: 398nMAssay Description:Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent