BDBM50445043 CHEMBL3098766::US10195186, Example 39::US9682967, 37

SMILES COc1cccc(NC(=O)c2ccc(cc2C(O)=O)C(F)(F)F)n1

InChI Key InChIKey=CVAINIUYHKSLAC-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50445043   

TargetSortilin(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445043(CHEMBL3098766 | US9682967, 37 | US10195186, Exampl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]-neurotensin from sortilin (unknown origin) incubated 30 mins prior to [3H]-neurotensin addition measured after 6 hrs by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSortilin(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445043(CHEMBL3098766 | US9682967, 37 | US10195186, Exampl...)
Affinity DataIC50: 7.50E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445043(CHEMBL3098766 | US9682967, 37 | US10195186, Exampl...)
Affinity DataKi:  1.24E+3nM IC50: 1.30E+3nMpH: 7.4Assay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetSortilin(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50445043(CHEMBL3098766 | US9682967, 37 | US10195186, Exampl...)
Affinity DataKi:  7.14E+3nMAssay Description:The Sortilin assay was performed in total volume of 40 ul in 50 mM HEPES pH 7.4 assay buffer containing 100 mM NaCl, 2.0 mM CaCl2, 0.1% BSA and 0.1% ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent