BDBM50444063 CHEMBL3092809::US9649309, Compound UNC2961A

SMILES CCCCNc1ncc(c(NC2CCNCC2)n1)-c1ccccn1

InChI Key InChIKey=ARSCEEUSPNVXQA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50444063   

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 34nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 34nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 34nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 55nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 430nMAssay Description:Inhibition of Tyro-3 kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetGrowth arrest-specific protein 6(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 433nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444063(CHEMBL3092809 | US9649309, Compound UNC2961A)
Affinity DataIC50: 3.09E+3nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent