BDBM50443636 CHEMBL3092460::US9174993, 1::US9221828, 1

SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2Cl)cc1

InChI Key InChIKey=MBNNXCKHRKSGSU-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50443636   

TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3nMAssay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The enzyme reaction was carried out in a buffer containing 25 mM Tris-HCl (pH 7.4), 5 mM MgCl2, 2 mM MnCl2, 2 mM DTT, and 0.03% bovine serum albumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Sgk2(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 924nMAssay Description:Inhibition of human SGK2 in presence of 500 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk3(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of human SGK3 in presence of 500 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 midazolam site in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human CYP3A4 testosterone site in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 442nMAssay Description:Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human SGK-1 expressed in baculovirus expression system using (5(6)-carboxyfluorescein)-RPRAATF-NH2 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi

US Patent
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)
Affinity DataIC50: 442nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed