BDBM50443354 CHEMBL3086035::US8669252, 23

SMILES Clc1ccc(cc1)C(NC(=O)[C@@H]1CC[C@H](C[C@H]1c1ccc(Br)cc1)N1CCOCC1)c1ccc(Cl)cc1

InChI Key InChIKey=AXXCMOIEGOZRPQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50443354   

TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50443354(CHEMBL3086035 | US8669252, 23)
Affinity DataIC50: 2.60nMAssay Description:The potency of compounds of formula I against PrCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PrCP inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50443354(CHEMBL3086035 | US8669252, 23)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50443354(CHEMBL3086035 | US8669252, 23)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed