BDBM50443343 CHEMBL3086028::US8669252, 56

SMILES CCN(CC)CC(=O)N[C@@H]1CC[C@H]([C@@H](C1)c1ccc(Br)cc1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1

InChI Key InChIKey=JMSGNVAFJFRXTL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50443343   

TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50443343(CHEMBL3086028 | US8669252, 56)
Affinity DataIC50: 17nMAssay Description:The potency of compounds of formula I against PrCP was determined by a fluorescence intensity kinetic assay measuring the IC50 values of PrCP inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2014
Entry Details
Go to US Patent

TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50443343(CHEMBL3086028 | US8669252, 56)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50443343(CHEMBL3086028 | US8669252, 56)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed