BDBM50443163 CHEMBL3085830::US8674100, 23

SMILES CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key InChIKey=PABZNWOXICIOPN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443163   

TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443163(CHEMBL3085830 | US8674100, 23)
Affinity DataIC50: 2.90nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443163(CHEMBL3085830 | US8674100, 23)
Affinity DataIC50: 5.10nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50443163(CHEMBL3085830 | US8674100, 23)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443163(CHEMBL3085830 | US8674100, 23)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of FMS in mouse BMDM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed