BDBM50442832 CHEMBL2441200

SMILES CC(C)OC(=O)N1CCN(CC1)c1ccc(NC(=O)c2oc(nc2C(F)(F)F)N2CCCCC2)cn1

InChI Key InChIKey=JDNUWBKKCJHGHA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50442832   

TargetDiacylglycerol O-acyltransferase 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442832(CHEMBL2441200)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of mouse DGAT-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442832(CHEMBL2441200)
Affinity DataIC50: 41nMAssay Description:Inhibition of human DGAT-1 expressed in insect Sf9 cell microsomes using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA as substrate after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442832(CHEMBL2441200)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) coincubated with substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442832(CHEMBL2441200)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) preincubated prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442832(CHEMBL2441200)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) preincubated prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed