BDBM50442179 CHEMBL2441619

SMILES Cc1ccc2c(c1)c(cc(n2)C(F)(F)F)N3CCNCC3

InChI Key InChIKey=ZKHOZLXKYFBVMY-UHFFFAOYSA-N

Data  1 KI  4 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50442179   

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50: 5.92E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Uit The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataKd:  3.33E+5nMAssay Description:Binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataIC50: 2.04E+5nMAssay Description:Inhibition of Axl (unknown origin) using 5'FAM labeled KKKKEEIYFFF-NH2 peptide as substrate incubated for 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50442179(CHEMBL2441619)
Affinity DataKi:  399nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed