BDBM50442174 CHEMBL2441565

SMILES CN(C)C\C=C\C(=O)N1CCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc12

InChI Key InChIKey=XHJPFLSAHTYUNW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50442174   

TargetCytochrome P450 2D6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide substrate preincubated for 10 mins followed by substrate addition measured after 40 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 319nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide substrate preincubated for 10 mins followed by substrate addition measured after 40 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50442174(CHEMBL2441565)
Affinity DataIC50: 14nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human KB cells preincubated for 1 hr followed by EGF stimulation measured after 6 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed