BDBM50442173 CHEMBL2441567

SMILES CN(C)C\C=C\C(=O)N1CCOc2cc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3cc12

InChI Key InChIKey=KPLGROMQFNWKJK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50442173   

TargetCytochrome P450 2D6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442173(CHEMBL2441567)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442173(CHEMBL2441567)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50442173(CHEMBL2441567)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2 after 20 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50442173(CHEMBL2441567)
Affinity DataIC50: 126nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed